Laboratoire de Bioingénierie et Biomatériaux Ostéo-Articulaires-UMR CNRS 7052, 10 Avenue de Verdun, 75010 Paris, France.
Osteoporos Int. 2011 Jun;22(6):2017-21. doi: 10.1007/s00198-011-1614-1.
Bioengineered bone scaffolds are intended for use in large bone defects. Successful bone constructs should stimulate and support both the onset and the continuance of bone ingrowth. In an attempt to improve their performance and to compete with the one of autologous bone grafts, a growing symbiosis at the biological and material level is required. Recent advances have been made to further exploit the osteogenic potential of MSCs in scaffold development. Current research encompasses new strategies for reducing cell death after implantation and the manufacturing of tailored, instructive scaffolds.
生物工程骨支架用于治疗大的骨缺损。成功的骨构建物应能刺激和支持骨长入的起始和持续。为了提高其性能并与自体骨移植物竞争，需要在生物学和材料层面上进行不断发展的共生关系。最近的进展已经在支架开发中进一步利用了间充质干细胞的成骨潜能。目前的研究包括减少植入后细胞死亡的新策略和定制、有指导作用的支架的制造。
