多米尼辛，一种环八肽，以及拉芬碱，一种溴吡咯生物碱，从加勒比海海绵Eurypon laughlini中分离得到。

Dominicin, a cyclic octapeptide, and laughine, a bromopyrrole alkaloid, isolated from the Caribbean marine sponge Eurypon laughlini.

作者信息

Williams David E, Patrick Brian O, Behrisch Hans W, Van Soest Rob, Roberge Michel, Andersen Raymond J

机构信息

Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada, V6T 1Z1.

出版信息

J Nat Prod. 2005 Mar;68(3):327-30. doi: 10.1021/np049711r.

DOI:10.1021/np049711r

PMID:15787430

Abstract

Dominicin, a new cyclic peptide, and the new bromopyrrole alkaloid laughine (4) have been isolated from the marine sponge Eurypon laughlini collected in Dominica. The structures of 1 and 4 were determined by a combination of spectroscopic analysis and chemical degradation. Single-crystal X-ray diffraction analysis confirmed the structure of dominicin (1).

摘要

从多米尼克采集的海洋海绵Eurypon laughlini中分离出了一种新的环肽多米尼克菌素以及新的溴吡咯生物碱拉芬（4）。通过光谱分析和化学降解相结合的方法确定了1和4的结构。单晶X射线衍射分析证实了多米尼克菌素（1）的结构。