Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12, 27570 Bremerhaven, Germany.
J Nat Prod. 2010 Apr 23;73(4):738-42. doi: 10.1021/np900664f.
In addition to the four known stylissamides, A (1), B (2), C, and D, two new cyclic heptapeptides, stylissamides E (3) and F (4), were isolated from the Caribbean sponge Stylissa caribica. The structures of 3 and 4 were elucidated from a combination of mass spectrometric and NMR spectroscopic data as cyclo-(cis-Pro(1)-Tyr(2)-trans-Pro(3)-Ala(4)-Ile(5)-Gln(6)-Ile(7)) for stylissamide E (3) and cyclo-(trans-Pro(1)-cis-Pro(2)-Phe(3)-Asp(4)-trans-Pro(5)-Arg(6)-Phe(7)) for stylissamide F (4).
此外，从加勒比海绵 Stylissa caribica 中分离到了除了已知的 4 种 stylissamides（1、2、C 和 D）外，还分离到了两种新的环状七肽，stylissamides E（3）和 F（4）。通过质谱和 NMR 光谱数据的组合，确定了 3 和 4 的结构，分别为环-(顺式-Pro(1)-Tyr(2)-反式-Pro(3)-Ala(4)-Ile(5)-Gln(6)-Ile(7)) 用于 stylissamide E（3）和环-(反式-Pro(1)-顺式-Pro(2)-Phe(3)-Asp(4)-反式-Pro(5)-Arg(6)-Phe(7)) 用于 stylissamide F（4）。
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