从两个野外采集的海洋蓝细菌样本中分离出swinholide A及相关糖基化衍生物。

Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria.

作者信息

Andrianasolo Eric H, Gross Harald, Goeger Douglas, Musafija-Girt Mirjam, McPhail Kerry, Leal Rachel M, Mooberry Susan L, Gerwick William H

机构信息

College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.

出版信息

Org Lett. 2005 Mar 31;7(7):1375-8. doi: 10.1021/ol050188x.

DOI:10.1021/ol050188x

PMID:15787510

Abstract

[structure: see text] Chemical investigation of two field collections of marine cyanobacteria has led to the discovery of two new cytotoxic natural products, ankaraholides A (2) and B (3), along with the known compound swinholide A (1). Since swinholide-type compounds were previously localized to the heterotrophic bacteria of sponges, these findings raise intriguing questions about their true metabolic source.

摘要

[结构：见正文] 对两批海洋蓝藻进行化学研究后，发现了两种新的具有细胞毒性的天然产物，安卡拉内酯A（2）和B（3），以及已知化合物斯氏大环内酯A（1）。由于斯氏大环内酯类化合物此前仅在海绵的异养细菌中发现，这些发现引发了关于其真正代谢来源的有趣问题。