Kobayashi M, Tanaka J, Katori T, Kitagawa I
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Chem Pharm Bull (Tokyo). 1990 Nov;38(11):2960-6. doi: 10.1248/cpb.38.2960.
Following the characterization of swinholide A (1), the major cytotoxic dimeric macrolide, three new congeneric dimeric macrolides, named swinholide B (2), swinholide C (3) and isoswinholide A (10), have been isolated from the Okinawan marine sponge Theonella swinhoei. The structures of these dimeric macrolides have been elucidated on the basis of chemical and physicochemical evidence. These dimeric macrolides were shown to exhibit potent cytotoxicities toward KB cell lines.
在对主要具有细胞毒性的二聚体大环内酯类化合物斯氏海绵素A（1）进行表征之后，从冲绳海洋海绵斯氏棘背海绵中分离出了三种新的同属二聚体大环内酯类化合物，分别命名为斯氏海绵素B（2）、斯氏海绵素C（3）和异斯氏海绵素A（10）。这些二聚体大环内酯类化合物的结构已根据化学和物理化学证据得以阐明。这些二聚体大环内酯类化合物对KB细胞系显示出强大的细胞毒性。
