Bishoyi Ajit Kumar, Mandhata Chinmayee Priyadarsani, Sahoo Chita Ranjan, Paidesetty Sudhir Kumar, Padhy Rabindra Nath
Central Research Laboratory, Institute of Medical Sciences and SUM Hospital, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, 751003, Odisha, India.
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to Be University, Bhubaneswar, 751003, Odisha, India.
Naunyn Schmiedebergs Arch Pharmacol. 2024 Mar;397(3):1347-1375. doi: 10.1007/s00210-023-02719-8. Epub 2023 Sep 15.
The Oscillatoria sp., a blue-green alga or cyanobacterium, consists of about 305 species distributed globally. Cyanobacteria are prokaryotes possessing several secondary metabolites that have industrial and biomedical applications. Particularly, the published reviews on Oscillatoria sp. have not recorded any pharmacology, or possible details, while the detailed chemical structures of the alga are reported in the literature. Hence, this study considers pertinent pharmacological activities of the plethora of bioactive components of Oscillatoria sp. Furthermore, the metallic nanoparticles produced with Oscillatoria sp. were documented for plausible antibacterial, antifungal, antioxidant, anticancer, and cytotoxic effects against several cultured human cell lines. The antimicrobial activities of solvent extracts of Oscillatoria sp. and the biotic activities of its derivatives, pyridine, acridine, fatty acids, and triazine were structurally described in detail. To understand the connotations with research gaps and provide some pertinent prospective suggestions for further research on cyanobacteria as potent sources of pharmaceutical utilities, attempts were documented. The compounds of Oscillatoria sp. are a potent source of secondary metabolites that inhibit the cancer cell lines, in vitro. It could be expected that by holistic exploitation, the natural Oscillatoria products, as the source of chemical varieties and comparatively more potent inhibitors, would be explored against pharmacological activities with the integument of SARs.
颤藻属（Oscillatoria sp.）是一种蓝藻或蓝细菌，由全球分布的约305个物种组成。蓝细菌是原核生物，拥有多种具有工业和生物医学应用的次生代谢产物。特别是，关于颤藻属的已发表综述未记录任何药理学或可能的细节，而该藻类的详细化学结构已在文献中报道。因此，本研究考虑了颤藻属大量生物活性成分的相关药理活性。此外，记录了用颤藻属制备的金属纳米颗粒对几种培养的人类细胞系具有合理的抗菌、抗真菌、抗氧化、抗癌和细胞毒性作用。详细描述了颤藻属溶剂提取物的抗菌活性及其衍生物吡啶、吖啶、脂肪酸和三嗪的生物活性。为了理解研究空白的内涵，并为将蓝细菌作为潜在药物来源的进一步研究提供一些相关的前瞻性建议，记录了相关尝试。颤藻属的化合物是次生代谢产物的有力来源，在体外可抑制癌细胞系。可以预期，通过全面开发，天然颤藻属产品作为化学品种的来源以及相对更有效的抑制剂，将结合构效关系来探索其药理活性。
