世界的“他汀奇迹”：万灵药还是即将破灭的泡沫。
The "Statinth" wonder of the world: a panacea for all illnesses or a bubble about to burst.
作者信息
Shafiq Nusrat, Malhotra Samir, Pandhi Promila, Grover Anil
机构信息
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
出版信息
J Negat Results Biomed. 2005 Mar 23;4:3. doi: 10.1186/1477-5751-4-3.
After the introduction of statins in the market as effective lipid lowering agents, they were shown to have effects other than lipid lowering. These actions were collectively referred to as 'pleiotropic actions of statins.' Pleiotropism of statins formed the basis for evaluating statins for several indications other than lipid lowering. Evidence both in favour and against is available for several of these indications. The current review attempts to critically summarise the available data for each of these indications.
他汀类药物作为有效的降脂药物进入市场后，人们发现它们除了具有降脂作用外，还有其他作用。这些作用被统称为“他汀类药物的多效性作用”。他汀类药物的多效性为评估其用于降脂以外的其他适应症奠定了基础。对于其中一些适应症，既有支持的证据，也有反对的证据。本综述试图对这些适应症的现有数据进行批判性总结。
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