刺五加根中木脂素的抗雌激素活性

Anti-estrogenic activity of lignans from Acanthopanax chiisanensis root.

作者信息

Lee Sanghyun, Yoo Hye Hyun, Piao Xiang Lan, Kim Ju Sun, Kang Sam Sik, Shin Kuk Hyun

机构信息

College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

出版信息

Arch Pharm Res. 2005 Feb;28(2):186-9. doi: 10.1007/BF02977713.

DOI:10.1007/BF02977713

PMID:15789749

Abstract

Anti-estrogenic activity of (-)-sesamin (1), helioxanthin (2), savinin (3), taiwanin C (4), and 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone (5) isolated from the root of Acanthopanax chiisanensis was tested using Ishikawa cells. Among them, compound 3 exhibited anti-estrogenic activity (IC50 = 4.86 microM).

摘要

从朝鲜五加（Acanthopanax chiisanensis）根部分离得到的（-）-芝麻素（1）、半日花素（2）、异落叶松脂素（3）、台湾脂素C（4）和3-（3,4-二甲氧基苄基）-2-（3,4-亚甲二氧基苄基）丁内酯（5）的抗雌激素活性，采用石川细胞进行了测试。其中，化合物3表现出抗雌激素活性（IC50 = 4.86 microM）。