了哥王根中的木脂素及其对PANC-1人胰腺癌细胞的细胞毒活性。
Lignans from the root of Wikstroemia indica and their cytotoxic activity against PANC-1 human pancreatic cancer cells.
作者信息
Chang Hang, Wang Yuwei, Gao Xue, Song Zehai, Awale Suresh, Han Na, Liu Zhihui, Yin Jun
机构信息
Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
出版信息
Fitoterapia. 2017 Sep;121:31-37. doi: 10.1016/j.fitote.2017.06.012. Epub 2017 Jun 16.
Six new compounds, wikstronin A (1), wikstronin B (2), wikstresinol (3), acetylwikstresinol (4), bis-5',5'-(+)-matairesinol (5), bis-5,5'-(+)-matairesinol (6), together with 20 known compounds (7-26) were isolated from the CHCl extract of roots of Wikstroemia indica. Structures of compounds 1-6 were determined by extensive NMR and CD spectroscopic analysis. In vitro preferential cytotoxicity of all the isolates was evaluated against a PANC-1 human pancreatic cell line. Compounds 8 and 12 displayed mild preferential cytotoxicity in the nutrient-deprived medium (NDM) and without causing toxicity in normal nutrient-rich conditions.
从了哥王根的氯仿提取物中分离出6个新化合物，即了哥王素A（1）、了哥王素B（2）、了哥王树脂醇（3）、乙酰了哥王树脂醇（4）、双-5',5'-(+)-罗汉松脂酚（5）、双-5,5'-(+)-罗汉松脂酚（6），以及20个已知化合物（7 - 26）。通过广泛的核磁共振和圆二色光谱分析确定了化合物1 - 6的结构。评估了所有分离物对PANC - 1人胰腺癌细胞系的体外选择性细胞毒性。化合物8和12在营养缺乏培养基（NDM）中表现出轻度的选择性细胞毒性，且在正常营养丰富的条件下不产生毒性。
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