Subhan Iqra, Siddique Yasir Hasan
Laboratory of Alternative Animal Models, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India.
CNS Neurol Disord Drug Targets. 2025;24(2):102-114. doi: 10.2174/0118715273326866240922193029.
Parkinson's Disease (PD) is a progressive disorder worldwide and its etiology remains unidentified. Over the last few decades, animal models of PD have been extensively utilized to explore the development and mechanisms of this neurodegenerative condition. Toxic and transgenic animal models for PD possess unique characteristics and constraints, necessitating careful consideration when selecting the appropriate model for research purposes. Animal models have played a significant role in uncovering the causes and development of PD, including its cellular and molecular processes. These models suggest that the disorder arises from intricate interplays between genetic predispositions and environmental influences. Every model possesses its unique set of strengths and weaknesses. This review provides a critical examination of animal models for PD and compares them with the features observed in the human manifestation of the disease.
帕金森病（PD）是一种全球性的进行性疾病，其病因尚未明确。在过去几十年中，帕金森病的动物模型已被广泛用于探索这种神经退行性疾病的发展和机制。帕金森病的毒性和转基因动物模型具有独特的特点和局限性，在选择适合研究目的的模型时需要仔细考虑。动物模型在揭示帕金森病的病因和发展，包括其细胞和分子过程方面发挥了重要作用。这些模型表明，该疾病源于遗传易感性和环境影响之间的复杂相互作用。每种模型都有其独特的优缺点。本综述对帕金森病的动物模型进行了批判性审视，并将它们与该疾病在人类表现中观察到的特征进行了比较。
