Mattioli G, Gentilino V, Caponcelli E, Martino F, Castagnetti M, Pini Prato A, Jasonni V
Department of Pediatric Surgery, Giannina Gaslini Research Institute, University of Genova, Italy.
Surg Endosc. 2004 Oct;18(10):1504-8. doi: 10.1007/s00464-003-9307-2. Epub 2004 Aug 24.
Surgical treatment of gastroesophageal reflux (GER) can result in many postoperative problems because of an incorrect indication or an unsuitable fundoplication. Many preoperative tests have been suggested to perform a "tailored fundoplication," but there is no clear evidence as to which is the best. The aim of our study was to define the effectiveness of esophageal manometry in predicting the outcome of children who need fundoplication because of refractory primary gastroesophageal reflux.
Thirty-two children were included in the study. Patients with gastroenterologic and respiratory symptoms numbered 10 (31%) and 22 (69%), respectively. The preoperative motility pattern was (1) inappropriate relaxations alone in nine patients (28%) and associated with esophageal body dysmotility in one patients (3%); (2) low-pressure lower esophageal sphincter (LES), alone in 13 patients (41%) and associated with body dysmotility in eight (25%). Motility pattern of the esophageal body was abnormal in nine children. Manometric anomalies were absent only in one case.
Low pressure of the LES associated with atypical esophageal motility disorders was significantly higher in the gastroenterological group and in the older patients. Low pressure of the LES associated with good esophageal activity was significantly higher in the respiratory group and in the patients younger than 24 months. There was no correlation between motility pattern and outcome, and no statistically significant differences were found between pressure values at the different levels and symptoms, outcome, and age groups.
Esophageal manometry is not mandatory to predict the outcome of patients undergoing laparoscopic Nissen-Rossetti fundoplication for refractory primary GER treatment.
由于适应证选择不当或胃底折叠术不合适,胃食管反流(GER)的手术治疗可能导致许多术后问题。许多术前检查被建议用于实施“个体化胃底折叠术”,但尚无明确证据表明哪种检查是最佳的。我们研究的目的是确定食管测压在预测因难治性原发性胃食管反流而需要进行胃底折叠术的儿童预后方面的有效性。
32名儿童纳入本研究。有胃肠症状和呼吸道症状的患者分别为10名(31%)和22名(69%)。术前动力模式为:(1)仅9名患者(28%)存在不适当松弛,其中1名患者(3%)伴有食管体部动力障碍;(2)13名患者(41%)存在低压下食管括约肌(LES),其中8名(25%)伴有体部动力障碍。9名儿童食管体部的动力模式异常。仅1例无测压异常。
在胃肠疾病组和年龄较大的患者中,与非典型食管动力障碍相关的LES低压明显更高。在呼吸道疾病组和年龄小于24个月的患者中,与良好食管活动相关的LES低压明显更高。动力模式与预后之间无相关性,不同水平的压力值与症状、预后及年龄组之间未发现统计学上的显著差异。
对于难治性原发性GER治疗,食管测压并非预测接受腹腔镜Nissen-Rossetti胃底折叠术患者预后的必需检查。