Kubik Paweł, Kowalska Bozena, Laskowska-Klita Teresa, Chełchowska Magdalena, Leibschang Jerzy
Klinika Połoznictwa i Ginekologii Instytutu Matki i Dziecka, Warszawie.
Przegl Lek. 2004;61(7):764-8.
We studied the effect of VIBOVITmama (Polfa Kutno S.A.) supplementation on the course of pregnancy duration, delivery and puerperium and also the status of zinc, copper and selenium in the blood of matched maternal-cord pairs. Healthy pregnant women (n=138) were divided by a double blinded trial into a test group taking vitamin and mineral supplementation containing 15 mg of zinc, 2 mg of copper and 20 microg of selenium and a control group taking placebo. Course of pregnancy, delivery and puerperium were analyzed, as well as concentration of bioelements in the blood serum of pregnant women in the I, II, and II trimester and in umbilical cord blood of their children. In the study group we noted fewer by 1.45% cases of pregnancy induced hypertension and a much higher rate of natural deliveries (75%) in comparison to the control group (53%). During pregnancy in the supplemented group a 1% increase of zinc serum concentration was found. In the control group zinc concentration decreased by 7% (p < 0.005). Insignificant differences in serum concentration of copper and selenium was observed between the study group and controls. In umbilical cord blood the differences in the concentration of the above microelements were also insignificant. The results allow for the statement that VIBOVITmama supplementation stabilizes the zinc, copper and selenium levels in blood of pregnant women without the risk of overdosing, especially with reference to selenium.
我们研究了VIBOVITmama（波兰库特诺制药厂）补充剂对孕期、分娩及产褥期过程的影响，以及配对的母婴血液中锌、铜和硒的状况。通过双盲试验将138名健康孕妇分为试验组和对照组，试验组服用含15毫克锌、2毫克铜和20微克硒的维生素和矿物质补充剂，对照组服用安慰剂。分析了孕期、分娩及产褥期过程，以及孕妇在孕早期、中期和晚期血清中生物元素的浓度及其子女脐带血中的浓度。与对照组（53%）相比，试验组妊娠高血压病例减少了1.45%，自然分娩率（75%）高得多。补充剂组孕期血清锌浓度增加了1%。对照组锌浓度下降了7%（p<0.005）。试验组与对照组血清铜和硒浓度差异不显著。脐带血中上述微量元素浓度差异也不显著。结果表明，VIBOVITmama补充剂可稳定孕妇血液中锌、铜和硒的水平，无过量风险，尤其是硒。
