Laskowska-Klita Teresa, Chełchowska Magdalena, Leibschang Jerzy
Zakład Biochemii i Diagnostyki Laboratoryjnej, Instytut Matki i Dziecka, Warszawie.
Przegl Lek. 2004;61(7):751-4.
Interest in assessing iron status in the population of women during their child-bearing age has grown recently both in terms of detecting iron stores and evaluating whether they are sufficient to meet increasing needs during pregnancy. The fact that iron deficiency anaemia often develops in pregnancy indicates that that iron stores and dietary iron are insufficient to requirements and iron supplementation is needed. The aim of the present study was to determine the effect of vitamin, macro and microelement supplementation on iron status of pregnant women and of their newborns. It is shown that serum total iron concentration in the group of women without supplementation decreased in the III trimester to 60% of that observed after 12 weeks of pregnancy (p < 0.0001). In supplemented group the decrease was not statistically significant. Increased value of transferin in III trimester in comparison to the I trimester by 38% (p < 0.0001) and by 55% (p < 0.0001) respectively in non supplemented and supplemented groups were found. It was accompanied by significant increase of total iron-binding capacity (TIBC) (p < 0.0001). In both studied groups the level of ferritin was lower in the III than in the I trimester. In serum of women without supplementation, ferritin concentration decreased by 35% (p < 0.003); whereas in supplemented group it was statistically insignificant. In serum of umbilical cord blood concentration of total iron, transferin and ferritin were similar in newborns of both groups of mothers. The above results suggested that vitamin, macro and microelement supplementation of pregnant women improved iron status in mothers and in their children. It seems that administration Vibovitmama formula can be recommended as a dietary supplement in pregnancy in order to prevent subclinical deficiency of iron.
近年来，人们对评估育龄期女性的铁状态越来越感兴趣，这包括检测铁储备以及评估这些储备是否足以满足孕期不断增加的需求。缺铁性贫血在孕期经常发生，这一事实表明铁储备和膳食铁不足以满足需求，需要进行铁补充。本研究的目的是确定维生素、常量和微量元素补充对孕妇及其新生儿铁状态的影响。结果显示，未补充组女性血清总铁浓度在妊娠晚期降至妊娠12周后观察值的60%（p < 0.0001）。在补充组中，这种下降没有统计学意义。在未补充组和补充组中，妊娠晚期转铁蛋白的值分别比妊娠早期增加了38%（p < 0.0001）和55%（p < 0.0001）。同时伴有总铁结合力（TIBC）显著增加（p < 0.0001）。在两个研究组中，铁蛋白水平在妊娠晚期均低于妊娠早期。在未补充组女性血清中，铁蛋白浓度下降了35%（p < 0.003）；而在补充组中，这一变化无统计学意义。两组母亲所生新生儿脐带血血清中的总铁、转铁蛋白和铁蛋白浓度相似。上述结果表明，孕妇补充维生素、常量和微量元素可改善母亲及其子女的铁状态。似乎可以推荐服用Vibovitmama配方作为孕期膳食补充剂，以预防铁的亚临床缺乏。
