Laskowska-Klita Teresa, Chełchowska Magdalena, Ambroszkiewicz Jadwiga, Kubik Paweł, Leibschang Jerzy
Zakład Biochemii i Diagnostyki Laboratoryjnej, Instytut Matki i Dziecka, Warszawie.
Przegl Lek. 2004;61(7):755-9.
The aim of the present study was to investigate the effect of Vibovitmama supplementation on status of fat soluble vitamins D, A (beta-carotene) and E in blood of pregnant women and in umbilical cord blood of their children. In group taking Vibovitmama serum concentration of vitamin D, was higher by 10% than in the placebo group was observed. However it was within the normal range and was not statistically significant. Supplementation affected vitamin D concentration in serum of cord blood. It was higher by 20% in the group taking vitamin preparation than in group taking placebo and was statistically significant (p < 0.05). Retinol and beta-carotene in plasma increased during pregnancy by 15% and 25% (p < 0.002) respectively in placebo and supplemented group. In umbilical cord blood in the group taking Vibovitmama, concentration of vitamin A was 1.52 micromol/L and of beta-carotene 1.86 micromol/L versus 1.45 micromol/L and 1.79 micro/L found in group of placebo. In plasma level, vitamin E was higher in late pregnancy than in the I trimester (by about 40%) and was not modified by vitamins supplementation. In erythrocytes the concentration of tocopherol increased by 18% in placebo and by 25% in group taking Vibovitmama. In the plasma of cord blood level of vitamin E was not modified by supplementation, whereas in red blood cells it was slightly increased (by 10%) but not statistically significant. Our results suggest that vitamin-mineral supplementation of pregnant women improved status of fat soluble vitamins in mothers and their children.
本研究的目的是调查补充复合维生素对孕妇血液及胎儿脐带血中脂溶性维生素D、A（β-胡萝卜素）和E水平的影响。服用复合维生素的组中，维生素D的血清浓度比安慰剂组高10%。然而，该浓度仍在正常范围内，且无统计学意义。补充复合维生素影响了脐带血血清中维生素D的浓度。服用维生素制剂的组比服用安慰剂的组高20%，且具有统计学意义（p<0.05）。安慰剂组和补充复合维生素组中，孕期血浆中视黄醇和β-胡萝卜素分别增加了15%和25%（p<0.002）。在服用复合维生素的组的脐带血中，维生素A浓度为1.52微摩尔/升，β-胡萝卜素浓度为1.86微摩尔/升，而安慰剂组分别为1.45微摩尔/升和1.79微摩尔/升。在血浆水平上，妊娠晚期维生素E高于孕早期（约高40%），且补充维生素并未对其产生影响。红细胞中，安慰剂组生育酚浓度增加了18%，服用复合维生素的组增加了25%。补充复合维生素并未改变脐带血血浆中维生素E的水平，而红细胞中维生素E水平略有增加（10%），但无统计学意义。我们的研究结果表明，孕妇补充维生素矿物质可改善母体及其子女的脂溶性维生素水平。
