在一名肾移植受者接受伐昔洛韦预防和短期更昔洛韦治疗后，早期筛选出一种对更昔洛韦磷酸化存在严重缺陷的新型UL97突变体。
Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient.
作者信息
Hantz Sébastien, Michel Detlef, Fillet Anne-Marie, Guigonis Vincent, Champier Gaël, Mazeron Marie-Christine, Bensman Albert, Denis François, Mertens Thomas, Dehee Axelle, Alain Sophie
机构信息
Department of Bacteriology-Virology-Hygiene, EA 3175, Teaching Hospital Dupuytren, Limoges cedex, France.
出版信息
Antimicrob Agents Chemother. 2005 Apr;49(4):1580-3. doi: 10.1128/AAC.49.4.1580-1583.2005.
Abstract
We describe the emergence of a new ganciclovir resistance mutation in the UL97 gene of human cytomegalovirus, deletion of codon 601, after valaciclovir and short-term ganciclovir therapy following kidney transplantation. Its role in ganciclovir resistance was supported by decreased ganciclovir phosphorylation in a recombinant vaccinia virus system.
摘要
我们描述了在肾移植后接受伐昔洛韦和短期更昔洛韦治疗后，人巨细胞病毒UL97基因中出现的一种新的更昔洛韦耐药性突变，即密码子601缺失。在重组痘苗病毒系统中，更昔洛韦磷酸化减少支持了其在更昔洛韦耐药性中的作用。
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J Med Virol. 2004 Aug;73(4):566-73. doi: 10.1002/jmv.20127.
2
Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs.
Hum Immunol. 2004 May;65(5):403-9. doi: 10.1016/j.humimm.2004.02.007.
3
Comparison of sequential cytomegalovirus isolates in a patient with lymphoma and failing antiviral therapy.
J Clin Virol. 2004 Apr;29(4):241-7. doi: 10.1016/S1386-6532(03)00163-X.
4
Efficacy and safety of lowering immunosuppression to treat CMV infection in renal transplant recipients on valaciclovir prophylaxis: a pilot study.
Nephrol Dial Transplant. 2003 Aug;18(8):1654-6. doi: 10.1093/ndt/gfg251.
5
Ganciclovir-resistant cytomegalovirus in organ transplant recipients.
Clin Infect Dis. 2002 Oct 1;35(7):866-72. doi: 10.1086/342385. Epub 2002 Sep 10.
6
Analysis and characterization of antiviral drug-resistant cytomegalovirus isolates from solid organ transplant recipients.
J Infect Dis. 2002 Sep 15;186(6):760-8. doi: 10.1086/342844. Epub 2002 Aug 28.
7
Emergence of multiple drug-resistant human cytomegalovirus variants in 2 patients with human immunodeficiency virus infection unresponsive to highly active antiretroviral therapy.
Clin Infect Dis. 2002 Apr 15;34(8):1146-9. doi: 10.1086/339750. Epub 2002 Mar 19.
8
Mutations in the UL97 ORF of ganciclovir-resistant clinical cytomegalovirus isolates differentially affect GCV phosphorylation as determined in a recombinant vaccinia virus system.
Antiviral Res. 2002 Apr;54(1):59-67. doi: 10.1016/s0166-3542(01)00211-x.
9
Cytomegalovirus UL97 phosphotransferase mutations that affect susceptibility to ganciclovir.
J Infect Dis. 2002 Jan 15;185(2):162-9. doi: 10.1086/338362. Epub 2001 Dec 17.
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