非酒精性脂肪性肝病
Nonalcoholic fatty liver disease.
作者信息
Adams Leon A, Angulo Paul, Lindor Keith D
机构信息
Division of Gastroenterology and Hepatology, Mayo Clinic and College of Medicine, Rochester, Minn 55905, USA.
出版信息
CMAJ. 2005 Mar 29;172(7):899-905. doi: 10.1503/cmaj.045232.
Abstract
Nonalcoholic fatty liver disease is emerging as the most common chronic liver condition in the Western world. It is associated with insulin resistance and frequently occurs with features of the metabolic syndrome. Disease presentation ranges from asymptomatic elevated liver enzyme levels to cirrhosis with complications of liver failure and hepatocellular carcinoma. Current treatment recommendations are limited to weight loss and exercise, although several promising medications are on the horizon. In this article we discuss the etiology, pathogenesis and diagnosis of nonalcoholic fatty liver disease as well as approaches to its management.
摘要
非酒精性脂肪性肝病正在成为西方世界最常见的慢性肝脏疾病。它与胰岛素抵抗相关，常伴有代谢综合征的特征。疾病表现范围从无症状的肝酶水平升高到肝硬化，并伴有肝衰竭和肝细胞癌等并发症。目前的治疗建议仅限于减肥和运动，不过有几种前景看好的药物即将问世。在本文中，我们将讨论非酒精性脂肪性肝病的病因、发病机制和诊断以及其管理方法。
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