Maio Ronald F, Shope Jean T, Blow Frederic C, Gregor Mary Ann, Zakrajsek Jennifer S, Weber James E, Nypaver Michele M
University of Michigan Injury Research Center, Department of Emergency Medicine, Ann Arbor, MI 48109-0437, USA.
Ann Emerg Med. 2005 Apr;45(4):420-9. doi: 10.1016/j.annemergmed.2004.10.013.
To determine whether an emergency department (ED)-based laptop computer intervention reduces the normative age-related increase in alcohol misuse compared with standard of care.
This was a randomized controlled trial conducted from October 11, 1999, to April 14, 2001, in a community teaching hospital and university medical center. Subjects were aged 14 to 18 years and with a minor injury. Controls and intervention participants completed a computer-based questionnaire. Intervention participants also completed a laptop-based interactive computer program to affect alcohol misuse. Main outcome measures were Alcohol Misuse Index (Amidx) and binge-drinking episodes. Follow-up occurred by telephone at 3 and 12 months. Analysis included repeated-measures analysis of variance (alpha=0.05; power 0.80; effect size 0.10).
Three hundred twenty-nine participants were randomized to the intervention group, and 326 participants were randomized to the control group. Two hundred ninety-five (89.7%) intervention subjects and 285 (87.4%) control subjects completed 3- and 12-month follow-ups. For intervention and control groups, respectively, mean age was 16.0 and 15.9 years and men composed 66.8% and 66.3% of the groups; Amidx scores were 2.2 and 2.0; binge-drinking episodes were 1.2 and 1.0. Outcomes for intervention and control, respectively, were Amidx (3 months) 1.5 and 1.4; Amidx (12 months) 1.8 and 2.1; binge drinking (3 months) 0.9 and 0.8; and binge drinking (12 months) 1.4 and 1.2. Overall, there were no significant effects (effect size 0.04). No detrimental effects were noted. Subgroup analysis suggested that the intervention may have an effect among subjects with experience drinking and driving (5% of the sample).
The intervention was not effective in decreasing alcohol misuse among the study population. Further research will be required to determine effectiveness among the subgroup of adolescent minor injury patients who have experience drinking and driving.
确定与标准治疗相比,基于急诊科的笔记本电脑干预措施是否能减少与年龄相关的酒精滥用现象。
这是一项于1999年10月11日至2001年4月14日在一家社区教学医院和大学医学中心进行的随机对照试验。研究对象年龄在14至18岁之间,且有轻伤。对照组和干预组参与者完成了一份基于计算机的问卷。干预组参与者还完成了一个基于笔记本电脑的交互式计算机程序,以影响酒精滥用情况。主要结局指标为酒精滥用指数(Amidx)和暴饮次数。在3个月和12个月时通过电话进行随访。分析包括重复测量方差分析(α = 0.05;检验效能0.80;效应量0.10)。
329名参与者被随机分配到干预组,326名参与者被随机分配到对照组。295名(89.7%)干预组受试者和285名(87.4%)对照组受试者完成了3个月和12个月的随访。干预组和对照组的平均年龄分别为16.0岁和15.9岁,男性分别占两组的66.8%和66.3%;Amidx评分分别为2.2和2.0;暴饮次数分别为1.2和1.0。干预组和对照组的结局分别为:Amidx(3个月)1.5和1.4;Amidx(12个月)1.8和2.1;暴饮(3个月)0.9和0.8;暴饮(12个月)1.4和1.2。总体而言,没有显著效果(效应量0.04)。未观察到有害影响。亚组分析表明,该干预措施可能对有酒后驾车经历的受试者(占样本的5%)有效果。
该干预措施在减少研究人群中的酒精滥用方面无效。需要进一步研究以确定在有酒后驾车经历的青少年轻伤患者亚组中的有效性。