Qiu Bensheng, Karmarkar Parag, Brushett Chris, Gao Fabao, Kon Ryan, Kar Sourav, Atalar Ergin, Yang Xiaoming
Department of Radiology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21287, USA.
Magn Reson Med. 2005 Apr;53(4):986-90. doi: 10.1002/mrm.20384.
The purpose of this study was to develop a standard 0.014-inch intravascular magnetic resonance imaging guidewire (MRIG), a coaxial cable with an extension of the inner conductor, specifically designed for use in the small vessels. After a theoretical analysis, the 0.014-inch MRIG was built by plating/cladding highly electrically conductive materials, silver or gold, over the inside and outside of the coaxial conductors. The conductors were made of superelastic, nonmagnetic, biocompatible materials, Nitinol or MP35N. Then, in comparison with a previously designed 0.032-inch MRIG, the performance of the new 0.014-inch MRIG in vitro and in vivo was successfully evaluated. This study represents the initial work to confirm the critical role of highly conductive and superelastic materials in building such small-size MRIGs, which are expected to generate high-resolution MR imaging of vessel walls/plaques and guide endovascular interventional procedures in the small vessels, such as the coronary arteries.
本研究的目的是开发一种标准的0.014英寸血管内磁共振成像导丝（MRIG），这是一种带有内导体延长部分的同轴电缆，专门设计用于小血管。经过理论分析，通过在同轴导体的内外表面电镀/包覆高导电材料（银或金）制成了0.014英寸的MRIG。导体由超弹性、非磁性、生物相容性材料（镍钛诺或MP35N）制成。然后，与先前设计的0.032英寸MRIG相比，成功评估了新型0.014英寸MRIG在体外和体内的性能。本研究是确认高导电和超弹性材料在制造此类小尺寸MRIG中关键作用的初步工作，这种小尺寸MRIG有望生成血管壁/斑块的高分辨率磁共振成像，并指导小血管（如冠状动脉）的血管内介入手术。
