Mathew Anna, Mathew M C
Continuing Medical Education Department, Christian Medical College, Vellore, T.Nadu, India.
Pediatr Rehabil. 2005 Jan-Mar;8(1):63-6. doi: 10.1080/13638490410001731180.
In work with children with cerebral palsy at Ashirvad, Child Development and Research Centre, Chennai, India, the authors were confronted with fretful children who resisted any attempt to mobilize their limbs due to hypertonia and muscle spasm. It was found that administering a bedtime dose of diazepam to reduce hypertonia and muscle spasm alongside passive stretching exercises significantly improved the behaviour of the child. There was significant improvement in the well-being of the child during the activities of daily living and this reduced the family's burden of caring for the child. In this double blind, placebo-controlled, randomized clinical trial, each child received a bedtime dose of diazepam or placebo. The bedtime diazepam relaxed the muscles and this made the passive stretching easy and the movements sustained the muscle relaxation during the day. There were fewer unwarranted crying spells during the day and less wakefulness during the night. The adverse effect of day time sedation was not observed with the use of a single dose of diazepam at bedtime.
在印度金奈阿希尔瓦德儿童发展与研究中心对脑瘫患儿开展的工作中，作者们遇到了烦躁不安的儿童，由于张力亢进和肌肉痉挛，他们抗拒任何活动其四肢的尝试。研究发现，在进行被动拉伸锻炼的同时，睡前服用一剂地西泮以减轻张力亢进和肌肉痉挛，可显著改善儿童的行为。在日常生活活动中，儿童的幸福感有显著改善，这减轻了家庭照顾孩子的负担。在这项双盲、安慰剂对照、随机临床试验中，每个孩子在睡前服用一剂地西泮或安慰剂。睡前服用地西泮可放松肌肉，这使得被动拉伸变得容易，并且这些动作在白天能维持肌肉放松。白天无端哭闹的情况减少，夜间觉醒也减少。睡前使用单剂量地西泮未观察到白天镇静的不良反应。
