Mathew Anna, Mathew M C, Thomas Molly, Antonisamy B
Developmental Paediatrics Unit, Christian Medical College & Hospital, Vellore 632004, Tamil Nadu, India.
J Trop Pediatr. 2005 Apr;51(2):109-13. doi: 10.1093/tropej/fmh095.
Muscle spasm and hypertonia limit mobility in children with spastic cerebral palsy. This double-blind, placebo-controlled, randomized controlled clinical trial studies the clinical efficacy of a low dose of diazepam in enhancing movement in children with spastic cerebral palsy. One hundred and eighty children fulfilled the criteria and were randomly allocated to receive one of two doses of diazepam or placebo at bedtime; 173 completed the study. There was a significant reduction of hypertonia, improvement in the range of passive movement, and an increase in spontaneous movement in the children who received diazepam. There was no report of daytime drowsiness. In developing countries, where cost factors often determine choice of drug, diazepam is a cheap and effective way of relieving spasm and stiffness, optimizing physical therapy and facilitating movement in children with spasticity.
肌肉痉挛和张力亢进限制了痉挛型脑瘫患儿的活动能力。这项双盲、安慰剂对照、随机对照临床试验研究了低剂量地西泮增强痉挛型脑瘫患儿运动能力的临床疗效。180名儿童符合标准，被随机分配在睡前接受两种剂量的地西泮或安慰剂中的一种；173名儿童完成了研究。接受地西泮治疗的儿童肌张力显著降低，被动运动范围改善，自发运动增加。没有关于日间嗜睡的报告。在成本因素常常决定药物选择的发展中国家，地西泮是缓解痉挛和僵硬、优化物理治疗并促进痉挛患儿活动的一种廉价而有效的方法。
