Sung Wang-Chou, Makamba Honest, Chen Shu-Hui
Department of Chemistry, National Cheng Kung University, No. 1 Ta-Hsueh Road, Tainan 701, Taiwan.
Electrophoresis. 2005 May;26(9):1783-91. doi: 10.1002/elps.200410346.
We present the current status of the development of microfluidic devices fabricated on different substrates for coupling with electrospray ionization-mass spectrometry (ESI-MS). Until now, much success has been gained in fabricating the ESI chips, which show better performances due to miniaturization when compared with traditional methods. Integration of multiple steps for sample preparation and ESI sample introduction, however, remains a great challenge. This review covers the main technical development of electrospray device that were published from 1997 to 2004. This article does not attempt to be exclusive. Instead, it focuses on the publications that illustrated the breath of the development and applications of microchip devices for MS-based analysis.
我们展示了在不同衬底上制造的用于与电喷雾电离质谱（ESI-MS）联用的微流控装置的当前发展状况。到目前为止，在制造ESI芯片方面已经取得了很大成功，与传统方法相比，由于小型化，ESI芯片表现出更好的性能。然而，将样品制备和ESI样品引入的多个步骤集成起来仍然是一个巨大的挑战。本综述涵盖了1997年至2004年发表的电喷雾装置的主要技术发展。本文并非试图做到详尽无遗。相反，它侧重于那些阐明了基于质谱分析的微芯片装置的发展广度和应用的出版物。
