Oh Jenny, Arkfeld Daniel G, Horwitz David A
Division of Rheumatology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90032, USA.
J Rheumatol. 2005 Apr;32(4):752-3.
In addition to its well known proinflammatory effects, tumor necrosis factor-alpha (TNF-a) has complex effects on the growth, differentiation, and death of immune cells. TNF antagonists have had dramatic effects on the suppression of rheumatoid arthritis and other rheumatic inflammatory diseases. However, TNF inhibition of RA has led to an increased incidence of drug induced anti-dsDNA production, with cases of systemic lupus erythematosus as well as exacerbations of multiple sclerosis. While etanercept does not generally alter the course of Crohn's disease we describe a rare instance where this agent may have contributed to the development of clinically significant inflammatory bowel disease.
除了其众所周知的促炎作用外，肿瘤坏死因子-α（TNF-α）对免疫细胞的生长、分化和死亡具有复杂的影响。TNF拮抗剂对类风湿性关节炎和其他风湿性炎症疾病的抑制作用显著。然而，TNF抑制类风湿性关节炎导致药物诱导抗双链DNA产生的发生率增加，出现了系统性红斑狼疮病例以及多发性硬化症的加重。虽然依那西普通常不会改变克罗恩病的病程，但我们描述了一个罕见的案例，在该案例中这种药物可能促成了具有临床意义的炎症性肠病的发展。
