Wang Lisa I, Giovannucci Edward L, Hunter David, Neuberg Donna, Su Li, Christiani David C
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Cancer Causes Control. 2004 Dec;15(10):977-85. doi: 10.1007/s10552-004-1093-1.
To evaluate possible interactions between dietary intake of cruciferous vegetables and the glutathione s-transferase mu and theta (GSTM1 and GSTT1) genotypes in lung cancer risk.
Hospital-based case-control study of 716 Caucasian lung cancer cases and 939 spouse and friend controls conducted in Boston, Massachussetts between 1992 and 2000. Dietary intake was collected through a food frequency questionnaire and blood was obtained for genotyping. Logistic regression models were adjusted for age, gender, total calories and smoking variables.
Higher intakes of cruciferous vegetables reduced lung cancer risk among GSTM1 present individuals (odds ratio (OR)highest versus lowest tertile = 0.61, 95% confidence interval (CI) = 0.39-0.95) but not among GSTM1 null individuals (OR(highest versus lowest tertile) = 1.15, 95% CI = 0.78-1.68). We observed statistically significant interactions between GSTM1 and cruciferous vegetable intake overall (likelihood ratio test (LRT): p = 0.05) and among current smokers (LRT: p = 0.01). No significant interactions were observed for GSTT1 or the combined GSTM1/T1 genotype.
In our study, higher cruciferous vegetable intake reduced lung cancer risk only among individuals with the GSTM1 present genotype. Our findings differed from prior studies that specifically assessed isothiocyanates found in cruciferous vegetables or evaluated Asian study populations with higher levels of cruciferous vegetable consumption.
评估十字花科蔬菜的膳食摄入量与谷胱甘肽S-转移酶μ和θ（GSTM1和GSTT1）基因型之间在肺癌风险方面可能存在的相互作用。
1992年至2000年在马萨诸塞州波士顿对716例白种人肺癌病例以及939名配偶和朋友对照进行了基于医院的病例对照研究。通过食物频率问卷收集膳食摄入量，并采集血液进行基因分型。逻辑回归模型针对年龄、性别、总热量和吸烟变量进行了调整。
十字花科蔬菜摄入量较高可降低GSTM1存在型个体的肺癌风险（最高三分位数与最低三分位数的比值比（OR）=0.61，95%置信区间（CI）=0.39-0.95），但在GSTM1缺失型个体中则不然（最高三分位数与最低三分位数的OR=1.15，95%CI=0.78-1.68）。总体上，我们观察到GSTM1与十字花科蔬菜摄入量之间存在统计学显著的相互作用（似然比检验（LRT）：p=0.05），在当前吸烟者中也是如此（LRT：p=0.01）。未观察到GSTT1或联合的GSTM1/T1基因型有显著的相互作用。
在我们的研究中，较高的十字花科蔬菜摄入量仅在具有GSTM1存在型基因型的个体中降低了肺癌风险。我们的研究结果与之前专门评估十字花科蔬菜中发现的异硫氰酸盐或评估十字花科蔬菜消费量较高的亚洲研究人群的研究不同。
