Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, ed 16, 90128 Palermo, Italy.
ATeN (Advanced Technologies Network) Center, Viale delle Scienze, University of Palermo, 90128 Palermo, Italy.
Nutrients. 2022 Dec 21;15(1):31. doi: 10.3390/nu15010031.
Inflammatory bowel disease (IBD) is a group of intestinal disorders, of unknown etiology, characterized by chronic inflammation within the gut. They are gradually becoming critical because of the increasing incidence worldwide and improved diagnosis. Due to the important side effects observed during conventional therapy, natural bioactive components are now under intense investigation for the prevention and treatment of chronic illnesses. The Brassicaceae family comprises vegetables widely consumed all over the world. In recent decades, a growing body of literature has reported that extracts from the Brassicaceae family and their purified constituents have anti-inflammatory properties, which has generated interest from both the scientific community and clinicians. In this review, data from the literature are scrutinized and concisely presented demonstrating that Brassicaceae may have anti-IBD potential. The excellent biological activities of Brassicacea are widely attributable to their ability to regulate the levels of inflammatory and oxidant mediators, as well as their capacity for immunomodulatory regulation, maintenance of intestinal barrier integrity and intestinal flora balance. Possible future applications of bioactive-derived compounds from Brassicaceae for promoting intestinal health should be investigated.
炎症性肠病（IBD）是一组肠道疾病，病因不明，其特征是肠道内的慢性炎症。由于全球发病率的增加和诊断水平的提高，这些疾病变得越来越重要。由于在常规治疗中观察到重要的副作用，天然生物活性成分现在正受到强烈关注，以预防和治疗慢性疾病。芸薹属蔬菜是一种在世界各地广泛食用的蔬菜。近几十年来，越来越多的文献报道称，芸薹属蔬菜及其纯化成分具有抗炎特性，这引起了科学界和临床医生的兴趣。在这篇综述中，仔细审查和简明呈现了文献中的数据，证明芸薹属可能具有抗 IBD 的潜力。芸薹属具有出色的生物学活性，这主要归因于其调节炎症和氧化介质水平的能力，以及其免疫调节调节、维持肠道屏障完整性和肠道菌群平衡的能力。应该研究芸薹属生物活性衍生化合物在促进肠道健康方面的未来应用。
