Russell Zoi, Riconda Dan, Pollack Lynda, O'Leary Timothy D, Carlan S J
Department of Obstetrics and Gynecology, Arnold Palmer Hospital for Children and Women, Orlando Regional Healthcare, Orlando, Florida, USA.
Obstet Gynecol. 2005 Apr;105(4):875-6. doi: 10.1097/01.AOG.0000141648.05771.24.
Symptomatic hemophilia A is a rare disorder in females. Pregnancy and delivery in such women can be life threatening. Obstetric management is challenging and requires a multidisciplinary approach to ensure a good outcome.
A woman with hemophilia A delivered by cesarean developed a deep vein thrombosis 10 days postpartum after recombinant factor VIII administration.
Hemophilia A due to skewed X-inactivation is a rare cause of peripartum bleeding. Recombinant factor VIII administration can prevent hemorrhage during and after cesarean delivery but may be associated with development of deep vein thrombosis.
有症状的甲型血友病在女性中是一种罕见疾病。此类女性的妊娠和分娩可能危及生命。产科管理具有挑战性，需要多学科方法以确保良好结局。
一名甲型血友病女性剖宫产分娩，产后10天在给予重组凝血因子VIII后发生深静脉血栓形成。
由于X染色体失活偏倚导致的甲型血友病是围产期出血的罕见原因。给予重组凝血因子VIII可预防剖宫产期间及术后出血，但可能与深静脉血栓形成有关。
