Safar M E, Asmar R G, Benetos A
Department of Internal Medicine, Hôpital Broussais, Paris, France.
Am J Med. 1992 Apr 27;92(4B):47S-53S. doi: 10.1016/0002-9343(92)90147-4.
Large artery dilation is produced by angiotensin-converting enzyme inhibition in hypertensive subjects despite a significant blood pressure reduction. The resulting increase in arterial compliance may be due both to blood pressure decrease and to arterial smooth muscle relaxation. In healthy volunteers and in hypertensive subjects, dosages causing large artery dilation seem to be higher than those causing pure arteriolar dilation with resulting blood pressure reduction. Similar findings have been noted to obtain compliance enhancement. Such results may be important in considering antihypertensive therapy, particularly when remodeling of the cardiovascular system is considered in long-term treatment.
尽管血压显著降低，但血管紧张素转换酶抑制在高血压患者中会引起大动脉扩张。动脉顺应性的增加可能是由于血压降低和动脉平滑肌松弛。在健康志愿者和高血压患者中，引起大动脉扩张的剂量似乎高于引起单纯小动脉扩张并导致血压降低的剂量。在获得顺应性增强方面也有类似的发现。这些结果在考虑抗高血压治疗时可能很重要，尤其是在长期治疗中考虑心血管系统重塑时。
