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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Internal Medicine, Broussais Hospital, Paris, France.

Clin Exp Pharmacol Physiol Suppl. 1992;19:29-32. doi: 10.1111/j.1440-1681.1992.tb02807.x.

Large artery dilatation may be produced by angiotensin-converting enzyme inhibition in hypertensive subjects independently of blood pressure reduction. The resulting increase in arterial compliance may be due to both blood pressure reduction and to arterial smooth muscle relaxation. 2. In healthy volunteers and in hypertensive subjects, dosages producing large artery dilatation seem to be even higher than those causing arteriole dilatation with the resulting blood pressure reduction. 3. It may be important to consider such findings for the remodelling of the cardiovascular system produced by angiotensin-converting enzyme inhibition.

血管紧张素转换酶抑制可使高血压患者的大动脉扩张，且与血压降低无关。由此导致的动脉顺应性增加可能归因于血压降低和动脉平滑肌松弛。2. 在健康志愿者和高血压患者中，产生大动脉扩张的剂量似乎甚至高于导致小动脉扩张并随之降低血压的剂量。3. 考虑血管紧张素转换酶抑制对心血管系统重塑的此类研究结果可能具有重要意义。

Department of Internal Medicine, Broussais Hospital, Paris, France.

Clin Exp Pharmacol Physiol Suppl. 1992;19:29-32. doi: 10.1111/j.1440-1681.1992.tb02807.x.

Large artery dilatation may be produced by angiotensin-converting enzyme inhibition in hypertensive subjects independently of blood pressure reduction. The resulting increase in arterial compliance may be due to both blood pressure reduction and to arterial smooth muscle relaxation. 2. In healthy volunteers and in hypertensive subjects, dosages producing large artery dilatation seem to be even higher than those causing arteriole dilatation with the resulting blood pressure reduction. 3. It may be important to consider such findings for the remodelling of the cardiovascular system produced by angiotensin-converting enzyme inhibition.

血管紧张素转换酶抑制可使高血压患者的大动脉扩张，且与血压降低无关。由此导致的动脉顺应性增加可能归因于血压降低和动脉平滑肌松弛。2. 在健康志愿者和高血压患者中，产生大动脉扩张的剂量似乎甚至高于导致小动脉扩张并随之降低血压的剂量。3. 考虑血管紧张素转换酶抑制对心血管系统重塑的此类研究结果可能具有重要意义。