新型吡唑并[3,4-d]哒嗪衍生物的抗菌和抗真菌活性
Antibacterial and antifungal activities of new pyrazolo[3,4-d]pyridazin derivatives.
作者信息
Akbas Esvet, Berber Ismet
机构信息
Organic Chemistry Division, Chemistry Department, Faculty of Arts and Sciences, Yuzuncu Yil University, 65080 Van, Turkey.
出版信息
Eur J Med Chem. 2005 Apr;40(4):401-5. doi: 10.1016/j.ejmech.2004.12.001.
Several new pyrazolo[3,4-d]pyridazin derivatives were prepared by the reaction of two [corrected] 1H-pyrazole-3-carboxylic acids and various hydrazines. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi. The compounds named as 7e, f had the highest antimicrobial activities against Gram-negative, Gram-positive bacteria and fungi with minimum inhibitory concentrations in the range of 0.31 to<0.0024 mg ml(-1) .
通过两种[校正后]的1H-吡唑-3-羧酸与各种肼的反应制备了几种新的吡唑并[3,4-d]哒嗪衍生物。测试了这些化合物对革兰氏阴性菌、革兰氏阳性菌和真菌的抗菌活性。命名为7e、f的化合物对革兰氏阴性菌、革兰氏阳性菌和真菌具有最高的抗菌活性，最低抑菌浓度在0.31至<0.0024 mg ml(-1)范围内。
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