Kumbar Mahadev N, Shaikh Saba Kauser J, Kamble Ravindra R, Bayannavar Praveen K, Kamble Atulkumar A, Hunnur Raveendra K
Department of Chemistry, Karnatak University, Dharwad 580003, Karnataka, India.
APL Research Centre (a division of Aurobindo Pharma Ltd. 313), Batchupally, Hyderabad 500 072, India.
ACS Omega. 2019 Mar 6;4(3):4955-4962. doi: 10.1021/acsomega.8b02013. eCollection 2019 Mar 31.
Fused nitrogen heterocyclesnamely, pyrazolo[3,4-]pyridazin-7(6)-ones have been obtained by exploiting the 1,3-dipolar nature of -arylsydnones, from hydrazones of 3-aryl-4-acetylsydnones the Vilsmeier-Haack strategy. Facile intramolecular nucleophilic addition followed by CO elimination under reflux or upon microwave irradiation was presented. Plausible mechanisms for the formation of the title compounds are proffered. Structure confirmatory evidence came from single-crystal X-ray crystallography.
稠合氮杂环，即吡唑并[3,4 - ]哒嗪 - 7(6) - 酮，是通过利用α - 芳基斯德酮的1,3 - 偶极性质，从3 - 芳基 - 4 - 乙酰基斯德酮的腙出发，采用维尔施迈尔 - 哈克策略制得的。本文展示了在回流或微波辐射下，通过分子内亲核加成然后消除CO的简便过程。还提出了形成标题化合物的合理机制。结构确证证据来自单晶X射线晶体学。
