Laird P P, Boray J C
Elizabeth Macarthur Agricultural Institute, NSW Agriculture, Camden, Australia.
Aust N Z J Med. 1992 Feb;22(1):45-7. doi: 10.1111/j.1445-5994.1992.tb01708.x.
Fascioliasis, caused by the common liver fluke Fasciola hepatica, is an endemic infection in sheep and cattle in many parts of Australia. Infections in humans in Australia have been reported infrequently and the most appropriate therapy for human fascioliasis remains to be determined. This case report describes a patient with the infection unsuccessfully treated with multiple high doses of praziquantel, mebendazole or albendazole. The infection was successfully eliminated by the administration of triclabendazole in two single doses of 900 mg (12 mg/kg) two days apart. No side effects were observed after the treatment. Based on our experience and that recently reported in the literature, triclabendazole may be regarded as the drug of choice for the treatment of human fascioliasis.
由常见的肝吸虫肝片吸虫（Fasciola hepatica）引起的肝片吸虫病，在澳大利亚许多地区是绵羊和牛的地方性感染病。澳大利亚关于人类感染的报告很少见，而治疗人类肝片吸虫病的最合适疗法仍有待确定。本病例报告描述了一名患者，其感染曾用多次高剂量的吡喹酮、甲苯达唑或阿苯达唑治疗但未成功。通过间隔两天分两次单剂量服用900毫克（12毫克/千克）三氯苯达唑成功消除了感染。治疗后未观察到副作用。根据我们的经验以及最近文献报道的情况，三氯苯达唑可被视为治疗人类肝片吸虫病的首选药物。
