Ayensu W K, Rezvani A H, Overstreet D H, Pucilowski O, Janowsky D S
Skipper Bowles Center for Alcohol Studies and Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599.
Alcohol Alcohol. 1992 Jan;27(1):47-54.
Depression and alcoholism are associated with impaired immune responses. Complement proteins and fragments participate in the induction and modulation of both specific and non-specific immune reactions. This study examined the effect of prolonged ethanol ingestion on complement CH50 levels in two strains of rats, the Flinders Resistant Line (FRL) and the Flinders Sensitive Line (FSL), that differ in cholinergic sensitivity and depressive tendencies. Chronic ethanol exposure given as either the source of drinking fluid or as a liquid diet had a significant inhibition on mean CH50 unit responses in both FSL (41-48%) and FRL (23-24%) rats. The difference in group response to ethanol was confirmed by a significant interaction of ethanol treatment versus group in the two-way ANOVA. The FSL rats appear to be more easily affected than FRLs. Genetic differences in the neurotransmitter systems, therefore, may play a role in susceptibility to immunosuppression resulting from ethanol exposure.
抑郁症和酗酒与免疫反应受损有关。补体蛋白和片段参与特异性和非特异性免疫反应的诱导和调节。本研究考察了长期摄入乙醇对弗林德斯抗性品系（FRL）和弗林德斯敏感品系（FSL）这两种大鼠补体CH50水平的影响，这两种品系在胆碱能敏感性和抑郁倾向方面存在差异。以饮用液体或流质饮食形式给予的慢性乙醇暴露对FSL大鼠（41%-48%）和FRL大鼠（23%-24%）的平均CH50单位反应均有显著抑制作用。在双向方差分析中，乙醇处理与组别的显著交互作用证实了两组对乙醇反应的差异。FSL大鼠似乎比FRL大鼠更容易受到影响。因此，神经递质系统的遗传差异可能在乙醇暴露导致免疫抑制的易感性中起作用。
