Jacob C O
Dept of Inflammation Biology and Immunology, Syntex Research, Palo Alto, CA 94303.
Immunol Today. 1992 Apr;13(4):122-5. doi: 10.1016/0167-5699(92)90107-i.
The role of TNF-alpha in the pathogenesis of autoimmune disorders is poorly understood. Evidence in favor of a pathogenic role has come mainly from in vitro experiments, while in vivo studies in animal models have suggested a protective role. In this article, Chaim Jacob attempts to reconcile these apparently contradictory studies.
肿瘤坏死因子-α（TNF-α）在自身免疫性疾病发病机制中的作用仍未被充分了解。支持其致病作用的证据主要来自体外实验，而动物模型的体内研究则表明它具有保护作用。在本文中，查姆·雅各布试图调和这些明显相互矛盾的研究。
