Moustaid Khadija, Nasser Boubker, Baudrimont Isabelle, Anane Rachid, El Idrissi Mostafa, Bouzidi Abdelhamid, Creppy Edmond E
Laboratoire de Chimie Organique, Faculté des Sciences, BP 4010, Beni M'hamed, Meknès, Maroc.
C R Biol. 2005 Mar;328(3):281-9. doi: 10.1016/j.crvi.2005.01.004.
Atlantic coast in mice. Preliminary studies showed that seawater contains heavy metals from domestic, agricultural and industrial wastes. Marine bivalves concentrate these pollutants by filtration and serve as vectors in human exposure. The objective of this study was to determine the concentration of heavy metals; cadmium (Cd); chromium (Cr), and lead (Pb) in mussels (Mytilus galloprovincialis) collected in two coastal sites; Jorf Lasfar (JL) (neighbouring a phosphate processing platform) and Oualidia (OL) (a vegetable growing area) located at 120 and 190 km south of Casablanca, respectively. Another objective was to test and compare the toxicity of these mussels on mice. The results indicated the presence of heavy metals (Cd, Cr, and Pb) in mussels at different concentrations, depending on the collection period. Higher concentrations were obtained at JL than at OL: for example, Cd concentrations were 80 +/- 15 to 199 +/- 28 versus 23 +/- 5 microg/g mussel dry weight, respectively. Cramming with mussel powder did not increase Cd, Cr, or Pb concentration in either liver or kidneys of treated mice. The relative kidney weights were reduced. Increased glucose urea was observed in animals' urine. Treatment with mussels from OL induced significant reduction (20%) in mice body weight, together with an increase in creatinuria. These results indicate that mussels collected from OL are more harmful than those obtained from JL are. All these mussels should not be recommended for human consumption.
小鼠体内的大西洋海岸情况。初步研究表明，海水中含有来自家庭、农业和工业废弃物的重金属。海洋双壳贝类通过过滤浓缩这些污染物，并成为人类接触这些污染物的载体。本研究的目的是测定在卡萨布兰卡以南120公里和190公里处的两个沿海地点采集的贻贝（Mytilus galloprovincialis）中重金属镉（Cd）、铬（Cr）和铅（Pb）的浓度。另一个目的是测试并比较这些贻贝对小鼠的毒性。结果表明，贻贝中存在不同浓度的重金属（Cd、Cr和Pb），这取决于采集时期。在约尔夫拉斯法尔（JL）（靠近一个磷酸盐加工平台）采集的贻贝中重金属浓度高于瓦利迪耶（OL）（一个蔬菜种植区）：例如，Cd浓度分别为80±15至199±28微克/克贻贝干重，而在OL采集的贻贝中Cd浓度为23±5微克/克贻贝干重。用贻贝粉填喂并未增加受试小鼠肝脏或肾脏中的Cd、Cr或Pb浓度。相对肾脏重量减轻。在动物尿液中观察到葡萄糖尿素增加。用OL采集的贻贝处理导致小鼠体重显著降低（20%），同时肌酸尿增加。这些结果表明，从OL采集的贻贝比从JL采集的贻贝危害更大。所有这些贻贝均不建议供人类食用。
