恶性疟原虫完全脂化糖基磷脂酰肌醇锚定物的汇聚合成。
Convergent synthesis of a fully lipidated glycosylphosphatidylinositol anchor of Plasmodium falciparum.
作者信息
Liu Xinyu, Kwon Yong-Uk, Seeberger Peter H
机构信息
Laboratory for Organic Chemistry, ETH Zürich, Wolfgang-Pauli-Str. 10, HCI F315, 8093 Zürich, Switzerland.
出版信息
J Am Chem Soc. 2005 Apr 13;127(14):5004-5. doi: 10.1021/ja042374o.
PMID:15810819
Abstract
A highly convergent strategy for the synthesis of fully lipidated GPI anchors of malarial origin is reported. This strategy utilized three orthogonal protecting groups, which can be chemoselectively deprotected and functionalized in the late stage of the synthesis. Rapid access to the target GPIs in a highly efficient manner in sufficient quantities for the biological studies has been achieved.
摘要
报道了一种用于合成疟疾来源的完全脂化糖基磷脂酰肌醇（GPI）锚的高度收敛策略。该策略使用了三种正交保护基，它们可以在合成后期进行化学选择性脱保护和官能化。已实现以高效方式快速获得足够数量的目标GPI用于生物学研究。
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