Wu Xiaoming, Guo Zhongwu
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA.
Org Lett. 2007 Oct 11;9(21):4311-3. doi: 10.1021/ol701870m. Epub 2007 Sep 18.
A fully phosphorylated GPI anchor (1) of the CD52 antigen was synthesized by a highly convergent strategy. After a trimannose and a phospholipidated pseudodisaccharide were prepared separately, they were coupled together to form the GPI core, which was then phosphorylated to introduce two phosphoethanolamine moieties in one step to afford CD52 GPI in its fully protected form. Finally, global deprotection of the product resulted in 1.
通过高度汇聚策略合成了完全磷酸化的CD52抗原糖基磷脂酰肌醇（GPI）锚（1）。在分别制备了一个三甘露糖和一个磷脂化假二糖后，将它们偶联在一起形成GPI核心，然后对其进行磷酸化，一步引入两个磷酸乙醇胺部分，得到完全保护形式的CD52 GPI。最后，对产物进行整体脱保护得到1。
