John A. Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA.
J Cataract Refract Surg. 2010 Aug;36(8):1392-7. doi: 10.1016/j.jcrs.2010.02.018.
To evaluate the safety to the retina of a light-delivery device used to irradiate a light-adjustable intraocular lens (IOL) after implantation in a rabbit model.
John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
In this study, rabbits had phacoemulsification with implantation of an ultraviolet (UV)-filtering light-adjustable IOL (study IOL) in 1 eye and a custom-made silicone IOL without a UV filter (control IOL) in the opposite eye. The study IOLs were irradiated at 1.0, 2.0, 3.0, and 5.0 times the expected maximum UV irradiation doses and the control IOLs, at 0.3, 0.6, 1.0, and 2.0 times. One week after irradiation, slitlamp and fundus (indirect ophthalmoscopy) examinations were performed. The rabbits were then humanely killed and their eyes enucleated and processed for histopathology.
The 16 eyes with the study IOL (with UV filter) showed no signs of corneal, anterior segment, or retinal toxicity on histopathologic evaluation. The 16 eyes with the control IOL (no UV filter) also showed no signs of corneal or anterior segment toxicity; however, 3 eyes receiving the higher radiation doses had focal areas of retinal damage consistent with laser burn.
Pigmented rabbit eyes with a light-adjustable IOL with a UV filter showed no signs of retina toxicity after near-UV light exposure up to 5 times the expected maximum treatment dosage.
No author has a financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes.
评估一种用于在兔模型中植入后辐照可调节型人工晶状体（IOL）的光传输装置对视网膜安全性。
美国犹他州盐湖城犹他大学约翰 A. 莫兰眼科中心。
在这项研究中，兔子行超声乳化白内障吸除术，其中一眼植入紫外线（UV）过滤型可调节 IOL（研究型 IOL），对侧眼植入无 UV 滤光片的定制型硅胶 IOL（对照型 IOL）。研究型 IOL 以预期最大 UV 照射剂量的 1.0、2.0、3.0 和 5.0 倍进行辐照，对照型 IOL 以 0.3、0.6、1.0 和 2.0 倍进行辐照。辐照后 1 周，行裂隙灯和眼底（间接检眼镜）检查。然后处死兔子，眼球摘出并进行组织病理学处理。
16 只植入研究型 IOL（带 UV 滤光片）的眼睛在组织病理学评估中未见角膜、眼前段或视网膜毒性的迹象。16 只植入对照型 IOL（无 UV 滤光片）的眼睛也未见角膜或眼前段毒性的迹象；然而，3 只接受较高辐射剂量的眼睛出现了与激光灼伤一致的视网膜局灶性损伤。
在接近 UV 光照射下，带有 UV 滤光片的可调节型人工晶状体的色素沉着兔眼，在接受 5 倍于预期最大治疗剂量的近 UV 光照射后，未见视网膜毒性迹象。
无作者在任何材料或方法上有财务或专有利益。其他披露情况见脚注。
