眼镜蛇蛇毒可显著降低人类乳腺癌组织中的核酸水平。
Cobra snake venom reduces significantly tissue nucleic acid levels in human breast cancer.
作者信息
Jokhio Rukhsana, Ansari Ahmed Farooq
机构信息
Department of Pliysilogy, University of Sindh, Jamshoro.
出版信息
J Pak Med Assoc. 2005 Feb;55(2):71-3.
OBJECTIVE
To look into the feasibility of using cobra snake venom in suppressing breast cancer tissue through inhibition of nucleic acid synthesis.
METHODS
Samples of breast cancerous tissue, obtained from Atomic Energy Medical Center, LMCH, Jamshoro, incubated with varying concentrations of venom and without venom (as controls) were assayed for macromolecular (RNA and DNA) levels
RESULTS
No. change in the control samples while a prominent and significant fall in nucleic acid contents has been noted in venom treated tissues. Also, maximum effect was observed with 25ug/ml dose.
CONCLUSION
Snake venom strongly inhibited the formation of nucleic acids in the breast cancerous tissues. It may bring a fall in cell proliferation, thus there is hope that venom could be used as an anti-cancerous drug in the future.
目的
探讨眼镜蛇蛇毒通过抑制核酸合成来抑制乳腺癌组织的可行性。
方法
从詹姆肖罗市拉合尔医学与牙科学院原子能医学中心获取乳腺癌组织样本，将其与不同浓度的蛇毒一起孵育，同时设置不添加蛇毒的样本作为对照，检测其大分子（RNA和DNA）水平。
结果
对照样本无变化，而在经蛇毒处理的组织中，核酸含量显著下降。此外，25微克/毫升剂量时观察到最大效果。
结论
蛇毒强烈抑制乳腺癌组织中核酸的形成。这可能会导致细胞增殖下降，因此有望在未来将蛇毒用作抗癌药物。
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