Hasler Gregor, Buysse Daniel J, Gamma Alex, Ajdacic Vladeta, Eich Dominique, Rössler Wulf, Angst Jules
Mood and Anxiety Disorders Program, Intramural Research Program, National Institutes of Health, National Institute of Mental Health, Bethesda, MD 20892, USA.
J Clin Psychiatry. 2005 Apr;66(4):521-9. doi: 10.4088/jcp.v66n0416.
Excessive daytime sleepiness (EDS) is a symptom with high clinical and public health importance because of its association with increased risk for accidents, decreased productivity, and impaired quality of life. Little information is available regarding the longitudinal course or clinical correlates of EDS. The aim of this study was to explore associations between self-reported EDS, sleep disorder symptoms, major depression, and anxiety in a longitudinal community study of young adults.
A prospective single-age community study of young adults (Zurich Cohort Study) was conducted from 1978 through 1999. Information was derived from 6 interviews administered when participants (N = 591) were ages 20, 22, 27, 29, 34, and 40 years. Trained health professionals administered a semistructured interview for health habits and psychiatric and medical conditions. The presence of either or both of 2 symptoms-accidentally falling asleep or excessive need for sleep during the day-was used to establish the presence of EDS.
EDS was a common complaint among the study participants, with increasing prevalence with age. Cross-sectionally, EDS was associated with insomnia symptoms, nocturnal hypersomnia, anxiety disorders, somatization, and reduced quality of life. Longitudinally, impaired sleep quality, waking up too early, and anxiety were associated with later EDS. Conversely, EDS was not significantly associated with later anxiety or depressive disorders.
Insomnia symptoms and anxiety are associated with the subsequent occurrence of EDS. Although these findings do not demonstrate causality, insomnia and anxiety disorders are prevalent and treatable conditions, and our results may have important clinical implications for the prevention and treatment of EDS. Whether the results of this study are limited to populations with elevated levels of psychopathology remains to be tested.
白天过度嗜睡(EDS)是一种具有高度临床和公共卫生重要性的症状,因为它与事故风险增加、生产力下降以及生活质量受损相关。关于EDS的纵向病程或临床相关因素的信息很少。本研究的目的是在一项针对年轻人的纵向社区研究中,探讨自我报告的EDS、睡眠障碍症状、重度抑郁症和焦虑之间的关联。
1978年至1999年进行了一项针对年轻人的前瞻性单年龄社区研究(苏黎世队列研究)。信息来自于对参与者(N = 591)在20、22、27、29、34和40岁时进行的6次访谈。训练有素的健康专业人员对健康习惯、精神和医疗状况进行半结构化访谈。使用意外入睡或白天过度嗜睡这两种症状中的一种或两种来确定EDS的存在。
EDS是研究参与者中常见的主诉,患病率随年龄增加。横断面分析显示,EDS与失眠症状、夜间睡眠过多、焦虑症、躯体化以及生活质量下降相关。纵向分析显示,睡眠质量受损、过早醒来和焦虑与后期的EDS相关。相反,EDS与后期的焦虑或抑郁症没有显著关联。
失眠症状和焦虑与随后发生的EDS相关。虽然这些发现并未证明因果关系,但失眠和焦虑症是普遍且可治疗的疾病,我们的结果可能对EDS的预防和治疗具有重要的临床意义。本研究结果是否仅限于精神病理学水平较高的人群仍有待检验。