Xue Fan, Zhang Yincheng, Liu Feng, Jing Jie, Ma Min
Department of Stomatology, Affiliated Hospital of Ningxia Medical College, Ningxia 750004, China.
J Oral Pathol Med. 2005 May;34(5):295-7. doi: 10.1111/j.1600-0714.2005.00312.x.
The aim of the present work was to study the potential effect of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and neural cell adhesion molecule (NCAM) of immunoglobulin superfamily on the invasion and metastasis of salivary adenoid cystic carcinoma (SACC).
The expressions of ICAM-1, VCAM-1 and NCAM of forty cases with SACC were examined by immunohistochemical methods using respective kits.
A significant relation showed between the expression level and histological differentiation, expression of ICAM-1 and VCAM-1 in solid SACC was greatly increased compared with NCAM; SACC with metastatic lymph node or local recurrence displayed significant relationship to the up-regulation of ICAM-1 and VCAM-1, and to the down-regulation of NCAM.
It is proposed that ICAM-1 and VCAM-1 may play a role in the invasion and metastasis of SACC. NCAM may be an invasion-resistant adhesion molecule.
本研究旨在探讨免疫球蛋白超家族的细胞间黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）和神经细胞黏附分子（NCAM）对涎腺腺样囊性癌（SACC）侵袭和转移的潜在影响。
采用相应试剂盒，通过免疫组化方法检测40例SACC患者ICAM-1、VCAM-1和NCAM的表达。
ICAM-1和VCAM-1的表达水平与组织学分级显著相关，实体型SACC中ICAM-1和VCAM-1的表达较NCAM显著增加；有淋巴结转移或局部复发的SACC与ICAM-1和VCAM-1的上调以及NCAM的下调显著相关。
提示ICAM-1和VCAM-1可能在SACC的侵袭和转移中发挥作用。NCAM可能是一种抗侵袭黏附分子。
