Fay Michael, Tan Alex, Fisher Richard, Mac Manus Michael, Wirth Andrew, Ball David
Department of Radiation Oncology, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1355-63. doi: 10.1016/j.ijrobp.2004.08.025.
To determine the relationship between various parameters derived from lung dose-volume histogram analysis and the risk of symptomatic radiation pneumonitis (RP) in patients undergoing radical radiotherapy for primary lung cancer.
The records of 156 patients with lung cancer who had been treated with radical radiotherapy (>/=45 Gy) and for whom dose-volume histogram data were available were reviewed. The incidence of symptomatic RP was correlated with a variety of parameters derived from the dose-volume histogram data, including the volume of lung receiving 10 Gy (V(10)) through 50 Gy (V(50)) and the mean lung dose (MLD).
The rate of RP at 6 months was 15% (95% confidence interval 9-22%). On univariate analysis, only V(30) (p = 0.036) and MLD (p = 0.043) were statistically significantly related to RP. V(30) correlated highly positively with MLD (r = 0.96, p < 0.001).
V(30) and MLD can be used to predict the risk of RP in lung cancer patients undergoing radical radiotherapy.
确定原发性肺癌根治性放疗患者肺剂量-体积直方图分析得出的各种参数与症状性放射性肺炎（RP）风险之间的关系。
回顾了156例接受根治性放疗（≥45 Gy）且有剂量-体积直方图数据的肺癌患者的记录。症状性RP的发生率与从剂量-体积直方图数据得出的各种参数相关，包括接受10 Gy（V(10)）至50 Gy（V(50)）的肺体积以及平均肺剂量（MLD）。
6个月时RP的发生率为15%（95%置信区间9 - 22%）。单因素分析显示，仅V(30)（p = 0.036）和MLD（p = 0.043）与RP有统计学显著相关性。V(30)与MLD高度正相关（r = 0.96，p < 0.001）。
V(30)和MLD可用于预测接受根治性放疗的肺癌患者发生RP的风险。
