Croft P, Cooper C, Wickham C, Coggon D
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital.
Br J Rheumatol. 1992 May;31(5):325-8. doi: 10.1093/rheumatology/31.5.325.
The authors examined the association of hip osteoarthritis with the presence of Heberden's nodes in a case-control study. Subjects were men aged 60-75 years who had undergone intravenous urography as out-patients. An examination of the hands was carried out in 240 patients who had a hip replacement for osteoarthritis or a joint space less than or equal to 2.5 mm, and in 290 controls whose joint space was greater than or equal to 3.5 mm in both hips. The presence of Heberden's nodes was associated with an increased risk of radiological hip osteoarthritis, the relationship being stronger in the 51 cases with severe joint-space narrowing (odds ratio = 3.4, 95% confidence interval 1.3-9.1). There was no evidence that this association differed according to the site of joint space narrowing within the hip. The finding provides further evidence that osteoarthritis of the hip can occur as part of a generalized process and does not only result from local damage to the joints.
作者在一项病例对照研究中，研究了髋骨关节炎与赫伯登结节的存在之间的关联。研究对象为60至75岁的男性门诊患者，这些患者曾接受静脉肾盂造影检查。对240例行髋骨关节炎置换术或关节间隙小于或等于2.5毫米的患者，以及290例双侧髋关节间隙大于或等于3.5毫米的对照者进行了手部检查。赫伯登结节的存在与放射性髋骨关节炎风险增加相关，在51例关节间隙严重变窄的病例中这种关系更强（比值比=3.4，95%置信区间1.3-9.1）。没有证据表明这种关联因髋关节内关节间隙变窄的部位不同而有所差异。这一发现进一步证明，髋骨关节炎可能是全身性过程的一部分，并非仅由关节局部损伤所致。
