Croft P, Cooper C, Wickham C, Coggon D
Medical Research Council, University of Southampton, Southampton General Hospital, United Kingdom.
Scand J Work Environ Health. 1992 Feb;18(1):59-63. doi: 10.5271/sjweh.1608.
This case-referent study investigated the relation between hip osteoarthritis and occupational activity. The subjects were 60- to 75-year-old men who had undergone intravenous urography. Interviews were obtained for 245 cases who had a hip replacement for osteoarthritis or a joint space of less than or equal to 2.5 mm and 294 referents whose joint space was greater than or equal to 3.5 mm in both hips. No clear associations were found in an analysis of all the cases, but severe disease (hip replacement for osteoarthritis or a joint space of less than or equal to 1.5 mm) was more common in the farmers, especially in those with greater than or equal to 10 years in agricultural work [odds ratio (OR) 2.0, 95% confidence interval (95% CI) 0.9-4.4]. Severe disease was also associated with prolonged standing at work (OR 2.7, 95% CI 1.0-7.3) and heavy lifting (OR 2.5, 95% CI 1.1-5.7). These associations could not be explained by obesity or sporting activity. The findings suggest an increased risk of degenerative hip disease for farmers and indicate that mechanical overloading may contribute to its pathogenesis.
这项病例对照研究调查了髋骨关节炎与职业活动之间的关系。研究对象为60至75岁接受过静脉肾盂造影的男性。对245例因骨关节炎接受髋关节置换或关节间隙小于或等于2.5毫米的病例以及294例双髋关节间隙大于或等于3.5毫米的对照者进行了访谈。在对所有病例的分析中未发现明确的关联，但严重疾病（因骨关节炎接受髋关节置换或关节间隙小于或等于1.5毫米）在农民中更为常见，尤其是从事农业工作10年及以上者[比值比（OR）为2.0，95%置信区间（95%CI）为0.9 - 4.4]。严重疾病还与工作时长时间站立（OR为2.7，95%CI为1.0 - 7.3）和重物搬运（OR为2.5，95%CI为1.1 - 5.7）有关。这些关联无法用肥胖或体育活动来解释。研究结果表明农民患退行性髋部疾病的风险增加，提示机械性过载可能在其发病机制中起作用。
