Lacaille Diane, Anis Aslam H, Guh Daphne P, Esdaile John M
University of British Columbia, and Arthritis Research Centre of Canada, Vancouver, British Columbia, Canada.
Arthritis Rheum. 2005 Apr 15;53(2):241-8. doi: 10.1002/art.21077.
Treatment guidelines for rheumatoid arthritis (RA) now recommend early, aggressive, and persistent use of disease-modifying antirheumatic drugs (DMARDs) to prevent joint damage in all people with active inflammation, and evaluation by a rheumatologist, when possible. This research assesses whether care for RA, at a population level, is consistent with current treatment guidelines.
Using administrative billing data from the Ministry of Health in 1996-2000, all prevalent RA cases in British Columbia, Canada were identified. Data were obtained on all medications and all provincially-funded health care services.
We identified 27,710 RA cases, yielding a prevalence rate of 0.76%, consistent with epidemiologic studies. DMARD use was inappropriately low. Only 43% of the entire RA cohort received a DMARD at least once over 5 years, and 35% over 2 years. When used, DMARDs were started in a timely fashion, but were not used consistently. Care by a rheumatologist increased DMARD use 31-fold. Yet, only 48% and 34% saw a rheumatologist over 5 and 2 years, respectively. DMARD use was significantly more frequent, persistent, and more often used as combination therapy with continuous rheumatologist care. DMARDs were used by 84% and 73%, 40%, and 10% of people followed by rheumatologists continuously and intermittently, internists, and family physicians, respectively (P < 0.001). NSAID use, physiotherapy, and orthopedic surgeries were similar across these 4 care groups.
RA care in the British Columbia population was not consistent with current treatment guidelines. Efforts to educate family physicians and consumers about the shift in RA treatment paradigms and to improve access to rheumatologists are needed.
类风湿关节炎(RA)的治疗指南现建议,对于所有有活动性炎症的患者,应尽早、积极且持续地使用改善病情抗风湿药(DMARDs)以预防关节损伤,并尽可能由风湿病专家进行评估。本研究评估在人群层面上,RA的治疗是否符合当前治疗指南。
利用1996 - 2000年加拿大不列颠哥伦比亚省卫生部的行政计费数据,识别出该省所有的RA现患病例。获取了所有药物及所有省级资助的医疗服务的数据。
我们识别出27710例RA病例,患病率为0.76%,与流行病学研究结果一致。DMARD的使用低得不合理。在整个RA队列中,仅43%的患者在5年内至少使用过一次DMARD,2年内使用过的比例为35%。DMARD在使用时开始得较为及时,但未持续使用。由风湿病专家诊治使DMARD的使用增加了31倍。然而,在5年和2年内分别仅有48%和34%的患者看过风湿病专家。在持续接受风湿病专家诊治的情况下,DMARD的使用显著更频繁、更持续,且更常作为联合治疗使用。在持续、间断接受风湿病专家诊治、内科医生诊治及家庭医生诊治的患者中,分别有84%、73%、40%及10%的患者使用了DMARD(P < 0.001)。在这4个治疗组中,非甾体抗炎药(NSAID)的使用、物理治疗及骨科手术情况相似。
不列颠哥伦比亚省人群中RA的治疗不符合当前治疗指南。需要努力对家庭医生和患者进行教育,使其了解RA治疗模式的转变,并改善获得风湿病专家诊治的机会。