Saatchi Katayoun, Thompson Katherine H, Patrick Brian O, Pink Maren, Yuen Violet G, McNeill John H, Orvig Chris
Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.
Inorg Chem. 2005 Apr 18;44(8):2689-97. doi: 10.1021/ic048186g.
Syntheses of vanadium complexes using the naturally occurring ligands isomaltol (Hima) and allomaltol (Hama), as well as a newly synthesized, potentially tetradentate diaminodipyrone [H(2)(en(ama)(2)], are reported. Complete characterization of the resulting compounds [trans-VO(ima)(2)(H(2)O), VO(ama)(2), V(ima)(3), V(ama)(3) and VO(en(ama)(2))], including X-ray crystallography analyses for trans-VO(ima)(2)(H(2)O) and V(ima)(3), are presented herein. Potentiometric titrations (25 degrees C, I = 0.16 M NaCl) were used to measure stability constants in the V(IV)-Hima system; these data were compared to previous data collected on the V(IV)-L (L = Hma, Hama) systems. The in vivo efficacy of these compounds to lower the blood glucose levels of STZ-diabetic rats was tested; all but VO(en(ama)(2)) produced significant decreases in plasma glucose levels. The results were compared to those of the benchmark compound BMOV [VO(ma)(2), bis(maltolato)oxovanadium(IV)], a known insulin-enhancing agent.
报道了使用天然存在的配体异麦芽醇（Hima）和别异麦芽醇（Hama）以及新合成的潜在四齿二氨基二吡喃酮[H₂(en(ama)₂)]合成钒配合物的方法。本文介绍了所得化合物[反式-VO(ima)₂(H₂O)、VO(ama)₂、V(ima)₃、V(ama)₃和VO(en(ama)₂)]的完整表征，包括对反式-VO(ima)₂(H₂O)和V(ima)₃的X射线晶体学分析。使用电位滴定法（25℃，I = 0.16 M NaCl）测量V(IV)-Hima体系中的稳定常数；这些数据与之前在V(IV)-L（L = Hma、Hama）体系中收集的数据进行了比较。测试了这些化合物降低链脲佐菌素诱导的糖尿病大鼠血糖水平的体内疗效；除VO(en(ama)₂)外，所有化合物均使血浆葡萄糖水平显著降低。将结果与基准化合物BMOV[VO(ma)₂，双（麦芽醇基）氧钒（IV），一种已知的胰岛素增强剂]的结果进行了比较。
