Baan M, Taverne M A M, Kooistra H S, de Gier J, Dieleman S J, Okkens A C
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, P.O. Box 80154, NL-3508 TD Utrecht, The Netherlands.
Theriogenology. 2005 Apr 15;63(7):1958-72. doi: 10.1016/j.theriogenology.2004.09.008.
The triggering mechanism for parturition in the bitch remains unclear. Consequently, the development of drugs to successfully induce parturition in the dog has been difficult. The aim of this study was to evaluate the efficacy of the progesterone-receptor blocker aglépristone for the induction of parturition in beagle bitches. The course of parturition was therefore investigated in six parturitions induced by aglépristone and in six spontaneous parturitions. In addition, data were collected on pup survival and growth rates. Aglépristone was administered twice with a 9h interval on day 58 of pregnancy. If parturition did not proceed a standard intervention protocol was applied. Expulsion of the first pup occurred between 32 and 56 h after the first treatment with aglépristone, at which time the plasma progesterone concentration was still elevated. Accordingly, the gestation length of the bitches in the induced group (59.5+/-0.2 days) was significantly shorter than that of the spontaneously whelping bitches (62.2+/-0.5 days). The expulsion phase length, the inter-pup interval, the number of puppies born dead, and the number of clinical interventions needed during parturition did not significantly differ between the spontaneously whelping and the induced group. Pup survival and mean birth weights in the two groups did not differ significantly and aglépristone treatment had no significant influence on the growth rates. The results of this study show that aglépristone is an effective drug which can be used safely for the induction of parturition in the dog.
母犬分娩的触发机制仍不清楚。因此，开发能成功诱导母犬分娩的药物一直很困难。本研究的目的是评估孕酮受体阻滞剂阿格列司酮诱导比格犬分娩的效果。因此，对6例由阿格列司酮诱导分娩的母犬和6例自然分娩的母犬的分娩过程进行了研究。此外，还收集了幼犬的存活率和生长率数据。在妊娠第58天，阿格列司酮间隔9小时给药两次。如果分娩未开始，则应用标准干预方案。首次给药阿格列司酮后32至56小时，第一只幼犬出生，此时血浆孕酮浓度仍处于升高状态。因此，诱导组母犬的妊娠期（59.5±0.2天）明显短于自然分娩母犬（62.2±0.5天）。自然分娩组和诱导组在分娩期长度、幼犬间隔时间、死产幼犬数量以及分娩期间所需的临床干预次数方面没有显著差异。两组幼犬的存活率和平均出生体重没有显著差异，阿格列司酮治疗对生长率没有显著影响。本研究结果表明，阿格列司酮是一种有效的药物，可安全用于诱导母犬分娩。
