Hua B, Li Q D, Wang F M
Naval General Hospital of PLA, Beijing.
Zhonghua Nei Ke Za Zhi. 1992 Oct;30(10):631-3, 659.
Serum antibody to Borrelia burgdorferi was measured in 33 patients with sarcoidosis who were confirmed clinically and pathologically. The results showed that 81.8% of the patients were positive. In addition, a strain of Borrelia burgdorferi was isolated from a patient's blood. Fourteen patients received ceftriaxone 2 g per day and/or penicillin 12 million per day and a patient received lincomycin 1.2 g per day. The antibody titer of the patients turned to normal level, their SACE turned to normal range, and chest X-ray findings were markedly improved in 3 cases after the treatment. According to the facts mentioned above, we consider that Borrelia burgdorferi may be the causal agent of sarcoidosis and sarcoidosis might be a special type of Lyme disease.
对33例经临床和病理确诊的结节病患者检测了抗伯氏疏螺旋体血清抗体。结果显示,81.8%的患者呈阳性。此外,从一名患者血液中分离出一株伯氏疏螺旋体。14例患者接受每日2克头孢曲松和/或每日1200万单位青霉素治疗,1例患者接受每日1.2克林可霉素治疗。治疗后,患者的抗体滴度恢复至正常水平,血清血管紧张素转换酶(SACE)恢复至正常范围,3例患者的胸部X线检查结果明显改善。根据上述事实,我们认为伯氏疏螺旋体可能是结节病的致病因子,结节病可能是莱姆病的一种特殊类型。