[结节病患者血清中伯氏疏螺旋体抗体的测定及其意义]

[Determination of antibody of Borrelia burgdorferi in the serum of patients with sarcoidosis and its significance].

作者信息

Chen Y Q, Miao J Z, Zhang X Z

机构信息

Beijing Hospital.

出版信息

Zhonghua Nei Ke Za Zhi. 1994 Jan;33(1):15-7.

PMID:8045180

Abstract

The level of antibody of Borrelia Burgdorferi in the serum of 40 patient, 23 with sarcoidosis and 17 without sarcoidosis was determined by using ELISA method. Antibody of BB was positive in the serum of 18 patients with sarcoidosis (78.3%). It is possible that sarcoidosis might be a disease of autoimmune abnormality and antibody of BB in the serum an auto-antibody resulting from the stimuli of certain unknown antigens. Cross reactivity may be present between the serological tests for sarcoidosis and those for rheumatic disease, tuberculosis, tumour and Lyme disease. But another case might be that antigen of BB is a mixture. Different antibodies of different disease react with different component of antigen of BB. Therefore, antibody of BB can not be considered as a specific test in the diagnosis of sarcoidosis.

摘要

采用酶联免疫吸附测定（ELISA）法检测了40例患者血清中伯氏疏螺旋体（Borrelia Burgdorferi，BB）抗体水平，其中23例为结节病患者，17例为非结节病患者。18例结节病患者血清中BB抗体呈阳性（78.3%）。结节病可能是一种自身免疫异常疾病，血清中的BB抗体可能是由某些未知抗原刺激产生的自身抗体。结节病的血清学检测与风湿性疾病、结核病、肿瘤及莱姆病的血清学检测之间可能存在交叉反应。但另一种情况可能是BB抗原是一种混合物。不同疾病的不同抗体与BB抗原的不同成分发生反应。因此，BB抗体不能被视为结节病诊断的特异性检测方法。