Uitti Ryan J, Baba Yasuhiko, Wszolek Zbigniew K, Putzke D John
Department of Neurology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Cannaday Bldg E-2, Jacksonville, FL 32224, USA.
Parkinsonism Relat Disord. 2005 May;11(3):139-45. doi: 10.1016/j.parkreldis.2004.10.007.
Examine the demographic and historical characteristics of a large Parkinson's disease (PD) clinical cohort and determine the pattern and relationship between initial symptoms of PD and physical examination ratings at the initial subspecialty clinic visit.
A clinical series of 1244 consecutive individuals diagnosed with PD. Baseline characteristics were examined.
The overall sample was predominantly right-handed (92%) male (67%), with a mean age of 70 years and symptomatic disease duration of about 7 years. About 25% of the sample reported a positive family history of a neurodegenerative disorder. Tremor (47%) and bradykinesia (29%) were the two most common initial symptoms of PD and occurred primarily in the upper extremities (68%). Tremor, bradykinesia, and postural instability showed a significant correspondence between the initial self-reported symptom and clinical signs at the first exam p < 0.05. However, rigidity did not show a significant correspondence.
The demographic and clinical characteristics of the sample are thought to be phenotypically representative of 'typical' PD and were comparable to other clinic- and population-based cohorts. Initial symptoms reported by patients, including type and body location correlate tightly with initial examination findings for all cardinal symptoms of parkinsonism except rigidity. This corroboration may substantiate inclusion of such data in studies of longitudinal progression in PD.
研究一个大型帕金森病（PD）临床队列的人口统计学和历史特征，并确定PD初始症状与初次专科门诊体格检查评分之间的模式及关系。
对连续诊断为PD的1244例个体进行临床系列研究。检查基线特征。
总体样本以右利手（92%）男性（67%）为主，平均年龄70岁，症状性疾病持续时间约7年。约25%的样本报告有神经退行性疾病家族史阳性。震颤（47%）和运动迟缓（29%）是PD最常见的两种初始症状，主要发生在上肢（68%）。震颤、运动迟缓及姿势不稳在初次自我报告症状与首次检查时的临床体征之间存在显著相关性（p<0.05）。然而，强直未显示出显著相关性。
该样本的人口统计学和临床特征在表型上被认为是“典型”PD的代表，且与其他基于门诊和人群的队列相当。患者报告的初始症状，包括类型和身体部位，与帕金森病所有主要症状（除强直外）的初始检查结果紧密相关。这种一致性可能证实将此类数据纳入PD纵向进展研究的合理性。
