Taşkapan Oktay, Harmanyeri Yavuz
Gülhane Military Medical Academy, Haydarpaşa Teaching Hospital, Department of Dermatology & Allergy, Istanbul, Turkey.
Acta Derm Venereol. 2005;85(2):123-5. doi: 10.1080/00015550410024139.
It is well known that the house dust and the scabies mites are related phylogenetically. We therefore performed atopy patch tests with house dust mite antigens (Dermatophagoides pteronyssinus (Dp) and/or Dermatophagoides farinae (Df)) in scabies patients without atopy and healthy controls. We studied 25 men with active scabies and 25 healthy controls. Skin prick tests with standardized house dust mite extract were performed for all patients and controls. An intradermal test procedure was carried out in skin prick test-negative patients, and for controls showing positive atopy patch test to Dp and/or Df. While atopy patch tests were performed directly in all healthy controls, patients with scabies were first treated and on the next day, atopy patch tests were performed. Twenty-two of 25 patients with scabies (88%) had skin prick test and/or intradermal test positivity against house dust mites, whereas 17/25 patients (68%) had atopy patch test positivity against house dust mites (Dp and/or Df). There was no statistically significant difference between skin prick test and/or intradermal test positivity and atopy patch test positivity in a regression analysis (p=0.222). The only statistically significant correlation was between atopy patch test positivity and the extent of scabies involvement (p<0.05). Only few of the healthy controls had positive tests. In this study, we have shown that a positive atopy patch test to house dust mite antigens is not specific for patients with atopic dermatitis, but also occurs in scabies patients without a history of atopic dermatitis.
众所周知，屋尘螨与疥螨在系统发育上有关联。因此，我们对无特应性的疥疮患者和健康对照者进行了屋尘螨抗原（粉尘螨（Dp）和/或屋尘螨（Df））的特应性斑贴试验。我们研究了25名患有活动性疥疮的男性和25名健康对照者。对所有患者和对照者进行了标准化屋尘螨提取物的皮肤点刺试验。对皮肤点刺试验阴性的患者以及对Dp和/或Df特应性斑贴试验呈阳性的对照者进行了皮内试验。所有健康对照者直接进行特应性斑贴试验，而疥疮患者首先接受治疗，第二天进行特应性斑贴试验。25名疥疮患者中有22名（88%）对屋尘螨的皮肤点刺试验和/或皮内试验呈阳性，而25名患者中有17名（68%）对屋尘螨（Dp和/或Df）的特应性斑贴试验呈阳性。回归分析显示，皮肤点刺试验和/或皮内试验阳性与特应性斑贴试验阳性之间无统计学显著差异（p = 0.222）。唯一具有统计学显著相关性的是特应性斑贴试验阳性与疥疮累及范围之间（p < 0.05）。只有少数健康对照者试验呈阳性。在本研究中，我们表明，对屋尘螨抗原的特应性斑贴试验阳性并非特应性皮炎患者所特有，也出现在无特应性皮炎病史的疥疮患者中。
