Reitamo S, Visa K, Kähönen K, Käyhkö K, Lauerma A I, Stubb S, Salo O P
Department of Dermatology, Helsinki University Central Hospital, Finland.
Acta Derm Venereol Suppl (Stockh). 1989;144:119-21.
To study whether inhalant allergens could induce eczematous reactions on normal skin of atopic patients we applied birch pollen and house dust mite antigens at 500 times the concentration used for prick testing as epicutaneous tests. Six out of 17 patients with atopic dermatitis in remission had positive delayed type reactions to birch pollen and three to house dust mite. Only one out of 13 atopic patients without history of atopic dermatitis but with seasonal allergic rhinitis had a positive patch test reaction to birch pollen and no patient had positive test reactions to house dust mite. No positive patch test reactions to birch pollen or house dust mite were seen in the ten healthy control subjects. In patients with positive test reactions biopsies from the test sites revealed epidermal spongiosis and vesiculation. Immunostaining of the epidermis revealed keratinocytes displaying both CD1 and HLA-DR. The present study suggests that inhalant allergens can exacerbate atopic dermatitis.
为研究吸入性变应原是否能在特应性患者的正常皮肤上诱发湿疹样反应，我们将桦树花粉和屋尘螨抗原以用于点刺试验浓度的500倍作为皮上试验进行应用。17例处于缓解期的特应性皮炎患者中有6例对桦树花粉出现阳性迟发型反应，3例对屋尘螨出现阳性迟发型反应。13例无特应性皮炎病史但患有季节性变应性鼻炎的特应性患者中只有1例对桦树花粉斑贴试验呈阳性反应，且无患者对屋尘螨试验呈阳性反应。10名健康对照者对桦树花粉或屋尘螨斑贴试验均未出现阳性反应。试验反应阳性的患者，试验部位活检显示表皮海绵形成和水疱形成。表皮免疫染色显示角质形成细胞同时表达CD1和HLA - DR。本研究提示吸入性变应原可加重特应性皮炎。
